Relia Tech/山羊抗人FAS配体，可溶性/100µg/102-P120G
市场价：
¥4700.00
美元价：
2820.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Cat-Nr. | 102-P120G |
| Size | 100 µg |
| Price | 235 € |
| Category | Polyclonal Antibody |
| Clone Nr. | Goat IgG |
| Species Reactivity | Human |
| Formulation | lyophilized from PBS |
| Buffer | PBS |
| Reconstitution | Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Stability and Storage | The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. |
| Preparation | Produced from sera of goats pre-immunized with highly pure (>98%) recombinant hFasL/Apo1L (human FAS Ligand/Apo1 Ligand). Anti-hFasL/Apo1L specific antibody was purified by affinity chromatography employing immobilized hFasL/Apo1L matrix. |
| Antigen | recombinant Human sFas Ligand |
| Application | ELISA, WB, N |
| Synonyms | FASLG; FASL; CD178; CD95L; CD95-L; TNFSF6; APT1LG1 |
| Description | Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a 40 kDa type II transmembrane member of the TNF superfamily of proteins. Its ability to induce apoptosis in target cells plays an important role in the development, homeostasis, and function of the immune system. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Both mouse and human Fas Ligand are active on mouse and human cells. Fas Ligand is expressed on the cell surface as a nondisulfidelinked homotrimer on activated CD4+ Th1 cells, CD8+ cytotoxic T cells, and NK cells. Fas Ligand binding to Fas/CD95 on an adjacent cell triggers apoptosis in the Fas expressing cell. Fas Ligand also binds DcR3 which is a soluble decoy receptor that interferes with Fas Ligandinduced apoptosis. Fas Ligand can be released from the cell surface by metalloproteinases as a 26 kDa soluble molecule which remains trimeric. Shed Fas Ligand retains the ability to bind Fas, although its ability to trigger apoptosis is dramatically reduced. In the absence of TGFβ, however, Fas Ligand/Fas interactions instead promote neutrophilmediated inflammatory responses. Fas Ligand itself transmits reverse signals that costimulate the proliferation of freshly antigenstimulated T cells. Fas Ligandinduced apoptosis plays a central role in the development of immune tolerance and the maintance of immune privileged sites. This function is exploited by tumor cells which evade immune surveillance by upregulating Fas Ligand to kill tumor infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lympho-proliferation and systemic autoimmunity. |
| Uniprot ID | P48023 |
| Protein RefSeq | NP_002980 |
| mRNA RefSeq | NM_000639.1 |
品牌介绍
Receptor Ligand Technologies GmbH 公司（RELIA Tech ）位于德国不伦瑞克，是一家后基因组生物技术公司，该公司运用独特的技术专注于受体和配体的发现与研究，从而使商业化，产品广泛使用于科学研究，实验诊断和临床应用。瑞莱技术的灵活性和竞争力必将使其在这个快速整合的功能基因组学和蛋白组学的新时代发展壮大.RELIA公司提供的细胞因子，生长因子，重组蛋白产品一致内毒素检测项目，且内毒素水平非常低。 受体配体技术有限公司（RELIATech）是一家后基因组生物技术公司，致力于在配体与受体相互作用领域的新技术和新产品的发现和商业化，用于研究，诊断和临床领域。该公司位于德国不伦瑞克，由以下公司成立于2000年10月： 阿夫纳·亚永教授以色列魏兹曼科学研究所（WIS） 赫伯特·韦奇博士德国生物技术德国研究中心（GBF） Bernhard Barleon博士德国肿瘤生物学诊所（KTB） 创始人是从事细胞生长因子相互作用，酪氨酸激酶及其信号传导途径（涉及组织重塑，体内平衡和疾病）领域的细胞和分子生物学家，工作时间超过10年。特别是Herbert A. Weich博士和Bernhard Barleon博士从事血管生成，肿瘤血管生成和实体瘤进展领域的基础研究。 诸如“生长因子和细胞因子”之类的信号蛋白，连同其跨膜/“可溶性受体”和相关的激酶，在生理和病理生理条件下都作为关键的调节分子参与了所有高级生物的发育和功能。这些多肽调节细胞分化，组织重塑和体内平衡，并在各种疾病状态下被失调。由人类基因组计划编码新信号蛋白的新生长调节基因的发现，以及对它们功能的阐明，无疑将是未来十年的主要挑战之一。 RELIATech的使命是开发和商品化在“受体和配体相互作用”领域中有用的新产品，用于基础研究，药物开发和临床社区。RELIATech的灵活性和能力必将使其在功能基因组学和蛋白质组学的新时代迅速整合和扩展。
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