Relia Tech/Human CD4, soluble/50 µg/S01-008
市场价：
¥3400.00
美元价：
2040.00
产品分类：
细胞代谢
公司分类：
cellular_metabolism
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Cat-Nr. | S01-008 |
| Size | 50 µg |
| Price | 170 € |
| Source | CHO cells |
| Formulation | lyophilized |
| Purity Confirmation | >95% by SDS-PAGE & HPLC analysis |
| Length [aa] | 371 |
| Molecular Weight | 41.3 kDa |
| Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
| Biological Activity | Determined by its ability to bind HeLa cells expressing cell-surface MHC-II molecules. |
| Species Reactivity | Human |
| Synonyms | Cluster determinant 4, T-cell surface glycoprotein CD4, Interleukin IL-16 receptor, T-cell surface antigen T4/Leu-3, Leu-3(a, b), OKT4(a-f), L3T4 (mouse) |
| Description | Cluster determinant 4 (CD4), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, playsan integral role in signal transduction and T-cell differentiation, development and activation. CD4 is constitutively expressed on thesurface of various immune cells, including monocytes, macrophages, eosinophils, dendritic cells, and most prominently Tlymphocytes,where it functions as an essential co-receptor and co-ligand for T-cell receptor (TCR) and major histocompatibilitycomplex class II (MHC-II) molecules. Ligation by MHC-II molecules on the surface of antigen-presenting cells can serve toinfluence adaptive immunity by facilitating helper T-cell activation and macrophage differentiation, while ligation by proinflammatorycytokine IL-16 can contribute to innate immunity by chemoattracting CD4-expressing peripheral immune cells alongan IL-16 gradient for their recruitment and activation at sites of inflammation. The protean functionality of CD4 extends pastimmunity as CD4 also notably serves as the major receptor for HIV-1 and human herpes virus 7 (HHV-7) infections. During HIVpathogenesis, CD4 acts instrumentally as a high-affinity entry receptor for the internalization of HIV-1 following binding of the viralenvelope glycoprotein gp120 to CD4’s extracellular domain. Recombinant Human sCD4 is amonomeric glycoprotein of 371 amino acid residues, which correspond to the extracellular CD4 domain, and a calculated molecularweight of 41.3 kDa. As a result of glycosylation, Recombinant Human sCD4 migrates with an apparent molecular mass of approximately 45-55 kDa by SDS-Page Gel analysis, under reducing conditions. |
| Protein Sequence | KKVVLGKKGD TVELTCTASQ KKSIQFHWKN SNQIKILGNQ GSFLTKGPSK LNDRADSRRS LWDQGNFPLI IKNLKIEDSD TYICEVEDQK EEVQLLVFGL TANSDTHLLQ GQSLTLTLES PPGSSPSVQC RSPRGKNIQG GKTLSVSQLE LQDSGTWTCT VLQNQKKVEF KIDIVVLAFQ KASSIVYKKE GEQVEFSFPL AFTVEKLTGS GELWWQAERA SSSKSWITFD LKNKEVSVKR VTQDPKLQMG KKLPLHLTLP QALPQYAGSG NLTLALEAKT GKLHQEVNLV VMRATQLQKN LTCEVWGPTS PKLMLSLKLE NKEAKVSKRE KAVWVLNPEA GMWQCLLSDS GQVLLESNIK VLPTWSTPVQ P |
| Uniprot ID | P06332 |
| Protein RefSeq | NP_038516.1 |
| mRNA RefSeq | NM_013488.2 |
品牌介绍
Receptor Ligand Technologies GmbH 公司（RELIA Tech ）位于德国不伦瑞克，是一家后基因组生物技术公司，该公司运用独特的技术专注于受体和配体的发现与研究，从而使商业化，产品广泛使用于科学研究，实验诊断和临床应用。瑞莱技术的灵活性和竞争力必将使其在这个快速整合的功能基因组学和蛋白组学的新时代发展壮大.RELIA公司提供的细胞因子，生长因子，重组蛋白产品一致内毒素检测项目，且内毒素水平非常低。 受体配体技术有限公司（RELIATech）是一家后基因组生物技术公司，致力于在配体与受体相互作用领域的新技术和新产品的发现和商业化，用于研究，诊断和临床领域。该公司位于德国不伦瑞克，由以下公司成立于2000年10月： 阿夫纳·亚永教授以色列魏兹曼科学研究所（WIS） 赫伯特·韦奇博士德国生物技术德国研究中心（GBF） Bernhard Barleon博士德国肿瘤生物学诊所（KTB） 创始人是从事细胞生长因子相互作用，酪氨酸激酶及其信号传导途径（涉及组织重塑，体内平衡和疾病）领域的细胞和分子生物学家，工作时间超过10年。特别是Herbert A. Weich博士和Bernhard Barleon博士从事血管生成，肿瘤血管生成和实体瘤进展领域的基础研究。 诸如“生长因子和细胞因子”之类的信号蛋白，连同其跨膜/“可溶性受体”和相关的激酶，在生理和病理生理条件下都作为关键的调节分子参与了所有高级生物的发育和功能。这些多肽调节细胞分化，组织重塑和体内平衡，并在各种疾病状态下被失调。由人类基因组计划编码新信号蛋白的新生长调节基因的发现，以及对它们功能的阐明，无疑将是未来十年的主要挑战之一。 RELIATech的使命是开发和商品化在“受体和配体相互作用”领域中有用的新产品，用于基础研究，药物开发和临床社区。RELIATech的灵活性和能力必将使其在功能基因组学和蛋白质组学的新时代迅速整合和扩展。
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