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当前位置: 首页 > 产品中心 > cellular_metabolism > Relia Tech/Human OX40 ligand, soluble/10 µg/S01-052
商品详细Relia Tech/Human OX40 ligand, soluble/10 µg/S01-052
Relia Tech/Human OX40 ligand, soluble/10 µg/S01-052
Relia Tech/Human OX40 ligand, soluble/10 µg/S01-052
商品编号: S01-052
品牌: reliatech
市场价: ¥3400.00
美元价: 2040.00
产地: 美国(厂家直采)
公司:
产品分类: 细胞代谢
公司分类: cellular_metabolism
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Cat-Nr.S01-052
Size10 µg
Price170 €
SourceInsect cells
Formulationlyophilized
Purity Confirmation> 97% by SDS-PAGE & HPLC analyses
Length [aa]133
Molecular Weight15.5-25 kDa
Endotoxin Levels< 0.1 ng/µg of protein (<1EU/µg)
Biological ActivityDetermined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 30-100 ng/ml. Note: Results may vary with PBMC donors.
Species ReactivityHuman
SynonymsTNFSF4; GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TAX transcriptionally-activated glycoprotein 1
DescriptionOX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. OX40/OX40L signaling plays an important role in immuno-regulatory communication, enabling the immune system to distinguish between “friend vs. foe” during activation; a mechanism typically termed immuno-tolerance. Recombinant OX40L is a glycosylated 133 amino acid protein corresponding to the extracellular TNF homologous domain of the full length transmembrane protein. It migrates with an apparent molecular mass of 15.5 – 25.0 kDa on SDS-PAGE.
Protein SequenceQVSHRYPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEFCVL
Uniprot IDP23510
Protein RefSeqNP_003317.1
mRNA RefSeqNM_003326.3
品牌介绍
Receptor Ligand Technologies GmbH 公司(RELIA Tech )位于德国不伦瑞克,是一家后基因组生物技术公司,该公司运用独特的技术专注于受体和配体的发现与研究,从而使商业化,产品广泛使用于科学研究,实验诊断和临床应用。瑞莱技术的灵活性和竞争力必将使其在这个快速整合的功能基因组学和蛋白组学的新时代发展壮大.RELIA公司提供的细胞因子,生长因子,重组蛋白产品一致内毒素检测项目,且内毒素水平非常低。 受体配体技术有限公司(RELIATech)是一家后基因组生物技术公司,致力于在配体与受体相互作用领域的新技术和新产品的发现和商业化,用于研究,诊断和临床领域。该公司位于德国不伦瑞克,由以下公司成立于2000年10月: 阿夫纳·亚永教授以色列魏兹曼科学研究所(WIS) 赫伯特·韦奇博士德国生物技术德国研究中心(GBF) Bernhard Barleon博士德国肿瘤生物学诊所(KTB) 创始人是从事细胞生长因子相互作用,酪氨酸激酶及其信号传导途径(涉及组织重塑,体内平衡和疾病)领域的细胞和分子生物学家,工作时间超过10年。特别是Herbert A. Weich博士和Bernhard Barleon博士从事血管生成,肿瘤血管生成和实体瘤进展领域的基础研究。    诸如“生长因子和细胞因子”之类的信号蛋白,连同其跨膜/“可溶性受体”和相关的激酶,在生理和病理生理条件下都作为关键的调节分子参与了所有高级生物的发育和功能。这些多肽调节细胞分化,组织重塑和体内平衡,并在各种疾病状态下被失调。由人类基因组计划编码新信号蛋白的新生长调节基因的发现,以及对它们功能的阐明,无疑将是未来十年的主要挑战之一。 RELIATech的使命是开发和商品化在“受体和配体相互作用”领域中有用的新产品,用于基础研究,药物开发和临床社区。RELIATech的灵活性和能力必将使其在功能基因组学和蛋白质组学的新时代迅速整合和扩展。