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当前位置: 首页 > 产品中心 > cytokine > Relia Tech/Mouse Gremlin-1/50µg/M30-025
商品详细Relia Tech/Mouse Gremlin-1/50µg/M30-025
Relia Tech/Mouse Gremlin-1/50µg/M30-025
Relia Tech/Mouse Gremlin-1/50µg/M30-025
商品编号: M30-025
品牌: reliatech
市场价: ¥3400.00
美元价: 2040.00
产地: 美国(厂家直采)
公司:
产品分类: 细胞因子
公司分类: cytokine
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Cat-Nr.M30-025
Size50 µg
Price170 €
SourceE. coli
Formulationlyophilized
Purity Confirmation> 95% by SDS-PAGE
Length [aa]161
Molecular Weight20.7 kDa
N Terminal SequenceMKKKGSQGAIPP
Biological ActivityData not available.
Species ReactivityMouse
Buffer50 mM acetic acid
ReconstitutionMouse Grem-1 should be reconstituted in 50 mM acetic acid or water to a concentration of 0.1mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
Stability and StorageThe lyophilized mouse Grem-1, though stable at room temperature, is best stored desiccated below 0°C
SynonymsGrem1; ld; Drm; Cktsf1b1
DescriptionGremlin was identified in a Xenopus expression cloning screen as a dorsalizing factor that can induce a secondary axis. A rat homolog, called Drm, was identified as a cDNA that was down regulated in v Mos transfected cells. Gremlin/Drm belongs to the DAN family of secreted glycoproteins that are BMP antagonists. Other members of the family include: Cerberus, Dante, PRDC, Caronte and DAN. DAN family members share a cysteine-rich domain that is structurally related to the cysteine-knot motif found in TGFβ superfamily ligands. In vitro, Gremlin/Drm binds BMP4 and BMP2 indicating that it might interfere with BMP signaling. Gremlin/Drm acts as a BMP2/ 4 antagonist in a variety of tissues and developmental processes including: Xenopus animal cap explants, chick limb bud outgrowth and chondrogenesis, murine lung branching morphogenesis, and osteogenic differentiation of mouse myoblasts and bone marrow stromal cells. In addition, expression of Gremlin/Drm has been shown to be down-regulated in a wide range of human cancer cell lines. Mouse, human, chick and Xenopus homologs of Gremlin share over 80% amino acid identity. It is likely that various DAN family members and other BMP antagonists including Noggin, Chordin, Follistatin and TSG can selectively antagonize the activities of different subsets of TGFβ superfamily ligands.
Protein SequenceMKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
Uniprot IDO70326
Protein RefSeqNP_035954.1
mRNA RefSeqNM_011824.4
品牌介绍
Receptor Ligand Technologies GmbH 公司(RELIA Tech )位于德国不伦瑞克,是一家后基因组生物技术公司,该公司运用独特的技术专注于受体和配体的发现与研究,从而使商业化,产品广泛使用于科学研究,实验诊断和临床应用。瑞莱技术的灵活性和竞争力必将使其在这个快速整合的功能基因组学和蛋白组学的新时代发展壮大.RELIA公司提供的细胞因子,生长因子,重组蛋白产品一致内毒素检测项目,且内毒素水平非常低。 受体配体技术有限公司(RELIATech)是一家后基因组生物技术公司,致力于在配体与受体相互作用领域的新技术和新产品的发现和商业化,用于研究,诊断和临床领域。该公司位于德国不伦瑞克,由以下公司成立于2000年10月: 阿夫纳·亚永教授以色列魏兹曼科学研究所(WIS) 赫伯特·韦奇博士德国生物技术德国研究中心(GBF) Bernhard Barleon博士德国肿瘤生物学诊所(KTB) 创始人是从事细胞生长因子相互作用,酪氨酸激酶及其信号传导途径(涉及组织重塑,体内平衡和疾病)领域的细胞和分子生物学家,工作时间超过10年。特别是Herbert A. Weich博士和Bernhard Barleon博士从事血管生成,肿瘤血管生成和实体瘤进展领域的基础研究。    诸如“生长因子和细胞因子”之类的信号蛋白,连同其跨膜/“可溶性受体”和相关的激酶,在生理和病理生理条件下都作为关键的调节分子参与了所有高级生物的发育和功能。这些多肽调节细胞分化,组织重塑和体内平衡,并在各种疾病状态下被失调。由人类基因组计划编码新信号蛋白的新生长调节基因的发现,以及对它们功能的阐明,无疑将是未来十年的主要挑战之一。 RELIATech的使命是开发和商品化在“受体和配体相互作用”领域中有用的新产品,用于基础研究,药物开发和临床社区。RELIATech的灵活性和能力必将使其在功能基因组学和蛋白质组学的新时代迅速整合和扩展。