
Relia Tech/Mouse IL-1 beta/10 µg/M10-013
市场价:
¥3400.00
美元价:
2040.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Cat-Nr. | M10-013 |
Size | 10 µg |
Price | 170 € |
Source | E. coli |
Formulation | lyophilized |
Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
Length [aa] | 153 |
Molecular Weight | 17.5 kDa |
Endotoxin Levels | < 0.1 ng/µg of protein (<1EU/µg) |
Biological Activity | The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.002 ng/ml, corresponding to a specific activity of ≥ 5 x 108 units/mg. |
Species Reactivity | Human, Monkey, Pig, Rat, Mouse |
Buffer | 10mM Sodium Citrate, pH 4.0 |
Reconstitution | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
Stability and Storage | The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 6 months at -20°C to -80°C. |
Synonyms | Il1b; Il-1b; IL-1beta |
Description | IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant murine IL-1β is a 17.5 kDa protein containing 153 amino acid residues. |
Protein Sequence | MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS |
Uniprot ID | P10749 |
Protein RefSeq | NP_032387 |
mRNA RefSeq | NM_008361 |
品牌介绍
Receptor Ligand Technologies GmbH 公司(RELIA Tech )位于德国不伦瑞克,是一家后基因组生物技术公司,该公司运用独特的技术专注于受体和配体的发现与研究,从而使商业化,产品广泛使用于科学研究,实验诊断和临床应用。瑞莱技术的灵活性和竞争力必将使其在这个快速整合的功能基因组学和蛋白组学的新时代发展壮大.RELIA公司提供的细胞因子,生长因子,重组蛋白产品一致内毒素检测项目,且内毒素水平非常低。 受体配体技术有限公司(RELIATech)是一家后基因组生物技术公司,致力于在配体与受体相互作用领域的新技术和新产品的发现和商业化,用于研究,诊断和临床领域。该公司位于德国不伦瑞克,由以下公司成立于2000年10月: 阿夫纳·亚永教授以色列魏兹曼科学研究所(WIS) 赫伯特·韦奇博士德国生物技术德国研究中心(GBF) Bernhard Barleon博士德国肿瘤生物学诊所(KTB) 创始人是从事细胞生长因子相互作用,酪氨酸激酶及其信号传导途径(涉及组织重塑,体内平衡和疾病)领域的细胞和分子生物学家,工作时间超过10年。特别是Herbert A. Weich博士和Bernhard Barleon博士从事血管生成,肿瘤血管生成和实体瘤进展领域的基础研究。 诸如“生长因子和细胞因子”之类的信号蛋白,连同其跨膜/“可溶性受体”和相关的激酶,在生理和病理生理条件下都作为关键的调节分子参与了所有高级生物的发育和功能。这些多肽调节细胞分化,组织重塑和体内平衡,并在各种疾病状态下被失调。由人类基因组计划编码新信号蛋白的新生长调节基因的发现,以及对它们功能的阐明,无疑将是未来十年的主要挑战之一。 RELIATech的使命是开发和商品化在“受体和配体相互作用”领域中有用的新产品,用于基础研究,药物开发和临床社区。RELIATech的灵活性和能力必将使其在功能基因组学和蛋白质组学的新时代迅速整合和扩展。
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